“NAD+ is the closest we’ve gotten to a fountain of youth. It’s one of the most important molecules for life to exist, and without it, you’re dead in 30 seconds.”
– David Sinclair, PhD – Harvard Medical School
CELLULAR ENERGY
Cellular energy is the foundation of all physical and cognitive performance. As we age or face chronic stress, the efficiency of our mitochondria — the powerhouses of our cells — naturally declines. This leads to persistent fatigue, slower recovery, and reduced mental stamina. Youphorin NAD+ is designed to address this at the root by supporting the body’s natural energy production pathways. The following sections detail how its key ingredients work synergistically to promote lasting vitality and cellular resilience.
Nicotinamide Riboside (NR)
Nicotinamide Riboside is a highly efficient precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme found in every living cell. NAD+ is essential for mitochondrial function, acting as a key electron transporter in the production of ATP (adenosine triphosphate), the primary energy currency of the body. Without sufficient NAD+, cellular energy production falters, leading to systemic fatigue.
Beyond energy metabolism, NAD+ is required for the activation of sirtuins, a family of proteins that regulate cellular health, DNA repair, and longevity. By elevating NAD+ levels, Nicotinamide Riboside supports these protective mechanisms, helping cells recover from stress and maintaining optimal function over time. This translates to sustained physical energy and sharper cognitive performance without the crash associated with stimulants.
How deficiency or decline can form:
NAD+ levels naturally decrease with age, but they can also be depleted by metabolic stress, poor diet, and lack of sleep. This decline compromises mitochondrial efficiency and cellular repair. Supplementing with Nicotinamide Riboside helps replenish NAD+ pools, restoring youthful cellular function.
Apigenin
Apigenin is a naturally occurring flavonoid found in plants like chamomile and parsley. In the context of cellular energy, apigenin plays a crucial supporting role by inhibiting an enzyme called CD38. CD38 is one of the primary consumers of NAD+ in the body, and its levels tend to increase with age and inflammation, accelerating the depletion of NAD+ stores.
By suppressing CD38 activity, apigenin helps preserve the NAD+ generated by Nicotinamide Riboside, ensuring that more of this vital coenzyme is available for energy production and cellular repair. This synergistic effect maximizes the efficacy of the supplement.
Furthermore, apigenin possesses strong antioxidant and anti-inflammatory properties. It helps protect cells from oxidative damage and supports a balanced nervous system, contributing to overall resilience and a calm, focused state of mind.
Clinical Research
Yoshino J, et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism. 2018;27(3):513-528.
Rajman L, et al. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism. 2018;27(3):529-547.
Camacho-Pereira J, et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metabolism. 2016;23(6):1127-1139.
Salehi B, et al. The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019;20(6):1305.